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KMID : 0613820090190081152
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Journal of Life Science
2009 Volume.19 No. 8 p.1152 ~ p.1158
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The Toxicological Pathologic Study of Amanita muscaria in Sprague-Dawley Rat
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Kim Jin
Kim Hyeong-Jin
Kim So-Jung
Kim Byeong-Soo
Kim Sang-Ki
Park Byung-Kwon
Park Young-Seok
Cho Sung-Dae
Jung Ji-Won
Nam Jeong-Seok
Choi Chang-Sun
Lee Seung-Ho
Jung Ji-Youn
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Abstract
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For the toxicological pathologic study of amanita muscaria, we have investigated single and repeated dose toxicity in Sprague-Dawley (SD) rats. Single dose toxicity study was identified as catalepsy, incline and tail pinch methods (control 0 ㎎/㎏, low 3.3 ㎎/㎏, middle 16.5 mg/kg, high 33.0 ㎎/㎏). Repeated dose toxicity study was carried out in blood tests, serum tests and histopathological methods. Neurotoxicity - muscle paralysis, and convulsion and loss of movement - was observed at 33.0 ㎎/㎏ group in the single dose toxicity study. Dysfunction of liver and kidney were shown in the repeated oral administration of the amanita muscaria at 3~4 weeks. Serum chemistry results revealed a marked increase of LDH [Lactate Dehydrogenase (3181.5 IU/ℓ; normal 230-460 IU/ℓ)], ALT [Alanine transaminase (124.0 IU/ℓ; normal <40 IU/ℓ)] but the kidney was normal. Histopathological results show interstitial edema and tubular epithelial necrosis in the kidney. These results suggest that amanita muscaria has a neurotoxic effect and causes dysfunction of liver and kidney in the SD rat.
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KEYWORD
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Amanita muscaria, neurotoxicity, dysfunction of liver and kidney
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